RXSOL
Lab Chemical
NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS
SKU: RXSOL-60-6605-027
N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides. Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.
Application
It is commonly used as the hindered base in amide coupling reactions between a carboxylic acid (typically activated, for example, as an acid chloride, as illustrated below) and a nucleophilic amine. As DIPEA is hindered and poorly nucleophilic, it does not compete with the nucleophilic amine in the coupling reaction.
Dosage
DIPEA is a good base used for deprotonation of carboxylic acid in peptides/amino acids to give you the intermediate carboxylate. It is added based on molar ratio.
