Application
Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline is being studied as an an experimental medicine but is approved in France as a combination topical gel product called Cicactive for small, superficial wounds.
Dosage
The daily turnover of collagen in humans is estimated to be 2–3 g/day,4 leading to the metabolism of 240–420 mg of hydroxyproline and the formation of 140–240 mg of glyoxylate